Research: Ginger (Sheng Jiang) Shows Effective Glycaemic Control Properties in Diabetes Mellitus


Preventive and Protective Properties of Zingiber officinale (Ginger) in Diabetes Mellitus, Diabetic Complications, and Associated Lipid and Other Metabolic Disorders: A Brief Review


Yiming Li, Van H. Tran, Colin C. Duke, and Basil D. Roufogalis



Zingiber officinale (ginger) has been used as herbal medicine to treat various ailments worldwide since antiquity. Recent evidence revealed the potential of ginger for treatment of diabetes mellitus. Data from in vitro, in vivo, and clinical trials has demonstrated the antihyperglycaemic effect of ginger. The mechanisms underlying these actions are associated with insulin release and action, and improved carbohydrate and lipid metabolism. The most active ingredients in ginger are the pungent principles, gingerols, and shogaol. Ginger has shown prominent protective effects on diabetic liver, kidney, eye, and neural system complications. The pharmacokinetics, bioavailability, and the safety issues of ginger are also discussed in this update.


Copyright © 2012 Li et al. This is an open access article distributed

under the terms of the Creative Commons Attribution License

1.              Introduction

2.              Antihyperglycaemic Effects of Zingiber officinale

1.           Results from Animal Studies

2.           Results from In Vitro Studies

3.           Results from Clinical Trials

3.              Mode of Action of Zingiber officinale on Glycaemic Control

1.           Ginger Inhibits Enzymes in Carbohydrate Metabolism

2.           Ginger Increases Insulin Release and Sensitivity

3.           Ginger Improves Lipid Profiles

4.              Protective Potential of Zingiber officinale for Diabetic Complications

1.           Protective Effect of Ginger on Liver

2.           Protective Effects of Ginger on Kidney

3.           Protective Effect of Ginger on the Central Nervous System

4.           Protective Effect of Ginger on the Eye

5.              Pharmacokinetics and Bioavailability of Ginger and Its Major Components

6.              Safety of Zingiber officinale

7.              Summary

8.              References


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