Effects of a Multi-Herbal Extract on Type 2 Diabetes
Jiyoung Yeo, Young-Mi Kang, Su-In Cho, Myeong-Ho Jung
Background: An aqueous extract of multi-hypoglycemic herbs of Panax ginseng C. A. Meyer, Pueraria lobata, Dioscorea batatas Decaisne, Rehmannia glutinosa, Amomum cadamomum Linné, Poncirus fructus and Evodia officinalis was investigated for its anti-diabetic effects in cell and animal models.
Methods: Activities of PPARg agonist, anti-inflammation, AMPK activator and anti-ER stress were measured in cell models and in db/db mice (a genetic animal model for type 2 diabetes).
Results: While the extract stimulated PPARg-dependent luciferase activity and activated AMPK in C2C12 cells, it inhibited TNF-a-stimulated IKKb/NFkB signaling and attenuated ER stress in HepG2 cells. The db/db mice treated with the extract showed reduced fasting blood glucose and HbA1c levels, improved postprandial glucose levels, enhanced insulin sensitivity and significantly decreased plasma free fatty acid, triglyceride and total cholesterol.
Conclusion: The aqueous extract of these seven hypoglycemic herbs demonstrated many therapeutic effects for the treatment of type 2 diabetes in cell and animal models.
Copyright © 2011 Yeo et al. This is an open access article distributed under the
Creative Commons Attribution License
1. Extract preparation
2. Cell lines
3. Reporter assays
4. Real-time RT-PCR
5. Western blot analysis
6. Animal study
7. Fasting blood glucose, blood HbA1c and plasma biomarker analyses
8. Intraperitoneal glucose tolerance test (IPGTT) and intraperitoneal insulin tolerance test (IPITT)
9. Statistical analysis
1. Effect on PPARg agonist
2. Effect on AMPK activation
3. Effect on inflammatory processes
4. Effect on attenuation of ER stress
5. Effects on body weight change and fasting blood glucose in db/db mice
6. Effects on postprandial glucose and insulin sensitivity in db/db mice
7. Effects on plasma lipids in db/db mice
8. Effects on glycosylated hemoglobin level and plasma biomarkers in db/db mice
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